For my fiancée's birthday this year I made her a custom version of the 4th Edition of Settlers of Catan based on Batman. After completing each tile I found an online printer and made the full game a reality. I also commissioned 3D Printed game pieces for the board as well. I did all of the design work in Photoshop.
Below are examples of some of the tiles that were ultimately printed. All design was done in Photoshop.
I also had custom cards made for the various needs of the game. Most of it is just text over comic book images.